Paired T-Test Sample Size Calculator

Free

Calculate the sample size (number of pairs) needed to detect a mean difference in paired or matched observations.

Study Parameters
Results

Required Sample Size

32

Achieved Power

80.7%

Effect Size

0.500

Method: Two-sided paired t-test
Number of pairs32
Cohen's d_z0.500
  • Paired (matched) observations
  • Normally distributed differences (or large sample via CLT)
  • Two-sided hypothesis test
Formula
n = (z_{alpha/2} + z_beta)^2 * sigma_d^2 / delta^2
References
  1. Chow SC, Shao J, Wang H (2008). Sample Size Calculations in Clinical Research, 2nd ed. Chapman & Hall/CRC.