Blog
Guides, tutorials, and insights on clinical trial design and biostatistics.
The Complete Guide to Sample Size Calculation for Clinical Trials
Everything you need to know about determining the right sample size for your clinical trial, from choosing parameters to handling dropouts.
January 15, 2025
Non-Inferiority Trials: How to Choose Your Margin
A practical guide to selecting and justifying the non-inferiority margin, with examples from regulatory submissions.
January 10, 2025
Cluster Randomized Trials: Design, Analysis, and Sample Size
How to properly design and power a cluster randomized trial, including ICC estimation and variable cluster sizes.
January 5, 2025
Adaptive Trial Designs: When and How to Use Them
An overview of adaptive designs including group sequential, sample size re-estimation, and response-adaptive randomization.
December 20, 2024
Understanding Power Analysis: Why 80% Isn't Always Enough
When to use 80% vs 90% power, how to interpret power curves, and common pitfalls in power analysis.
December 15, 2024
ICH E9(R1) Estimand Framework: A Practical Guide
How the estimand framework changes the way we think about trial design, endpoints, and statistical analysis.
December 10, 2024
Sample Size for Survival Endpoints: Log-Rank vs Cox
Comparing methods for calculating sample size for time-to-event endpoints, including Schoenfeld, Freedman, and Lakatos.
December 5, 2024
Equivalence vs Non-Inferiority: What's the Difference?
A clear explanation of the difference between equivalence and non-inferiority designs, with guidance on when to use each.
November 30, 2024
10 Common Mistakes in Clinical Trial Sample Size Calculations
Avoid these frequent errors that lead to underpowered or unnecessarily large trials.
November 25, 2024
Free vs Paid Sample Size Calculators: What You're Missing
A comparison of free online calculators, commercial software, and what features actually matter for your research.
November 20, 2024